Diterpenoid alkaloids from Delphinium gracile

Two highly oxygenated hetisine- type diterpenoid alkaloids, delphigraciline ( 1), 14- hydroxyhetisinone N- oxide ( 2), and the norditerpenoid alkaloid 8- methoxykarakoline ( 3), were isolated from a neutral extract of Delphinium gracile. Their structures were elucidated on the basis of spectroscopic data and by comparison with previously reported spectroscopic data of similar alkaloids. Their antiparasitic and insecticidal activities are also discussed.