4.5 Article

Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis

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ACTA DERMATO-VENEREOLOGICA
卷 87, 期 2, 页码 127-134

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ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-0184

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HLA-C antigens; psoriatic arthritis; guttate psoriasis; nail; anti-psoriatic drugs

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The PSORS1 locus is the consistently replicated genetic risk factor for psoriasis. Clinical associations with the main marker allele of PSORS1, HLA-Cw6, have been addressed in a number of studies, but clinical associations have not been used as a way to distinguish the effects of the neighbouring candidate genes in PSORS1. Our results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. The clinical profiling of a small group of patients (n = 34) who were HLA-Cw6- but CCHCR1*WWCC positive suggested that no great differences existed between them and HCR-Cw6- patients. HCR+ genotype (as well as Cw6+ genotype) correlated for the first time positively with female sex and, in contrast with previous studies, negatively with disease severity. Presence of psoriatic arthritis was more pronounced in HCR-psoriasis (as well as in Cw6- psoriasis). Clinical profiling may be a useful approach to distinguishing genetic effects of candidate genes even within a locus in sufficiently large cohorts.

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