期刊
DEVELOPMENTAL CELL
卷 12, 期 1, 页码 157-166出版社
CELL PRESS
DOI: 10.1016/j.devcel.2006.10.017
关键词
-
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM039341, R29GM039341] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM039341, GM39341] Funding Source: Medline
The Drosophila PAN GU (PNG) kinase complex regulates the developmental translation of cyclin B. cyclin B mRNA becomes unmasked during oogenesis independent of PNG activity, but PNG is required for translation from egg activation. We find that although polyadenylation of cyclin B augments translation, it is not essential, and a fully elongated poly(A) is not required for translation to proceed. In fact, changes in poly(A) tail length are not sufficient to account for PNG-mediated control of cyclin B translation and of the early embryonic cell cycles. We present evidence that PNG functions instead as an antagonist of PUMILIO-dependent translational repression. Our data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据