期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 85, 期 1, 页码 70-72出版社
CARDEN JENNINGS PUBL CO LTD
DOI: 10.1532/IJH9706129
关键词
chronic granulomatous disease; McLeod phenotype; reduced-intensity conditioning; umbilical cord blood; transplantation; aspergillosis
类别
Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition. We successfully treated a 20-year-old man with very rare McLeod phenotype CGD with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.
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