期刊
NATURE CLINICAL PRACTICE ONCOLOGY
卷 4, 期 9, 页码 516-525出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncponc0908
关键词
breast cancer; self-renewal; stem cell; subtypes; therapy
类别
资金
- Breast Cancer Now [2006MAYSF01] Funding Source: Medline
This Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据