期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1772, 期 4, 页码 446-456出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2006.10.007
关键词
tau; cell cycle; neurodegeneration; Alzheimer's disease; TOR; target of rapamycin; mitogenic signaling; apoptosis; Drosophila melanogaster; invertebrate model
资金
- NATIONAL INSTITUTE ON AGING [P50AG005134, R01AG019790, K08AG000880] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG019790, P50 AG005134] Funding Source: Medline
Studies in cell-culture systems and in postmortem tissue from human disease have suggested a connection between cell-cycle activation and neurodegeneration. The fruit fly Drosophila melanogaster has recently emerged as a powerful model system in which to model neurodegenerative diseases. Here we review work in the fly that has begun to address some of the important questions regarding the relationship between cell-cycle activation and neurodegeneration in vivo, including recent data implicating cell-cycle activation as a downstream effector of tau-induced neurodegeneration. We suggest how powerful research tools in Drosophila might be utilized to approach fundamental questions that remain. (c) 2006 Elsevier B.V. All rights reserved.
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