期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 152, 期 1, 页码 1-10出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2006.11.013
关键词
leishmaniasis; trypanosomiasis; malaria; cryptosporidiosis; S-adenosylmethionine; methionine adenosyltransferase; methylation; Polyamines; chemotherapy
S-adenosylmethionine is one of the most frequently used enzymatic substrates in all living organisms. It plays a role in all biological methyl transfer reactions in as much as it is a donor of propylamine groups in the synthesis of the polyamines spermidine and spermine, it participates in the trans-sulphuration pathway to cysteine one of the three amino acids involved in glutathione and trypanothione synthesis in trypanosomatids and finally it is a source of the 5-deoxyadenosyl radicals, which are involved in many reductive metabolic processes, biodegradative pathways, tRNA modification and DNA repair. This mini-review is an update of the progress on the S-adenosylmethionine synthesis in different representative protozoan parasites responsible for many of the most devastating so-called tropical diseases that have an enormous impact on global health. (c) 2006 Elsevier B.V. All rights reserved.
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