期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 33, 期 9, 页码 909-926出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040701498759
关键词
melt extrusion; thermal processing; solid dispersion; solid molecular dispersion; extruder; bioavailability; sustained release; immediate release; drug delivery systems
资金
- NCRR NIH HHS [P20 RR021929] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR021929] Funding Source: NIH RePORTER
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据