期刊
JOURNAL OF ASTHMA
卷 44, 期 8, 页码 605-608出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02770900701540028
关键词
asthma; alpha-1 antitrypsin deficiency; genetic screening
In a study comparing low-dose theophylline to montelukast in poorly controlled asthmatics, 285 subjects consented to be screened for alpha-1 antitrypsin deficiency. Of the 284 for which complete data was available, 10.5% carried a deficiency gene and 2.4% were mildly deficient with an alpha-1 antitrypsin serum level of less than 20 mu M. In the non-African-American cohort, an abnormal phenotype occurred in 12% and 2.9% were mildly deficient. Baseline pulmonary function and asthma scores were not significantly different between those with normal and abnormal AAT phenotype. However those with the deficiency tended to show a greater bronchodilator response.
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