期刊
CURRENT DRUG TARGETS
卷 8, 期 1, 页码 31-47出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945007779315524
关键词
Plasmodium; Toxoplasma; Cryptosporidium; nucleotide biosynthesis; salvage pathways; drug resistance; drug targets; folate metabolism
资金
- Wellcome Trust [056845, 073896] Funding Source: Medline
Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines represent the fundamental requirements for their eventual assembly into nucleic acids as nucleotides and the deployment of their derivatives in other biochemical pathways. A small number of drugs targeted to nucleotide metabolism, by virtue of their effect oil folate biosynthesis and recycling, have been successfully used against apicomplexan parasites such as Plasmodium and Toxoplasma for many years, although resistance is now a major problem in the prevention and treatment of malaria. Many targets not involving folate metabolism have also been explored at the experimental level. However, the unravelling of the genome sequences of these eukaryotic unicellular organisms, together with increasingly sophisticated molecular analyses, opens up possibilities of introducing new drugs that could interfere with these processes. This review examines the status of established drugs of this type and the potential for further exploiting the vulnerability of apicomplexan human pathogens to inhibition of this key area of metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据