期刊
PROTEIN AND PEPTIDE LETTERS
卷 14, 期 2, 页码 113-124出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986607779816096
关键词
CcdB-CcdA; MazF-MazE; plasmid maintenance; RelE-RelB; ribonuclease
Toxin-antitoxin systems were discovered as plasmid auxiliary maintenance cassettes. In recent years, an increasing amount of structural and functional information has become available about the proteins involved, allowing the understanding of bacterial cell growth inhibition by the toxins on a molecular level. A well-studied TA system is formed by the proteins Kid and Kis, encoded by the parD operon of the Escherichia coli plasmid R L The toxicity of Kid has been related to its endoribonuclease activity, which is counteracted by binding of the antitoxin Kis at the proposed active site. In this review, the structural studies on the Kid-Kis system are compared to those of three related toxin-antitoxin systems: MazF-MazE, CcdB-CcdA and RelE-RelB.
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