期刊
MICROBIOLOGY AND IMMUNOLOGY
卷 51, 期 11, 页码 1115-1119出版社
WILEY
DOI: 10.1111/j.1348-0421.2007.tb04007.x
关键词
Cryptococcus neoformans; dectin-1; host defense; dendritic cells; IL-12
Dectin-1 is known as a sole receptor for P-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C neoformans.
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