期刊
DRUG DISCOVERY TODAY
卷 12, 期 1-2, 页码 28-33出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2006.10.006
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067761] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01GM067761] Funding Source: Medline
RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi screening platform that we have established and made available to the community through the Drosophila RNAi Screening Center at Harvard Medical School. We then illustrate how the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery.
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