期刊
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
卷 4, 期 1, 页码 42-50出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpcardio0728
关键词
aspirin; cyclo-oxygenase; drug interaction; platelet aggregation; thromboxane
The term aspirin resistance has been used increasingly in clinical studies. The aim of this Review is to analyze the origin of this term, to discuss the biochemical, functional and clinical correlates of the phenomenon and to offer a conceptual framework to redefine the major determinants of variability between individuals in response to aspirin. Awareness needs to be increased of factors that might interfere with the desired antiplatelet effect of aspirin, particularly in terms of patients' adherence to treatment and avoidable drug interactions with some traditional NSAIDs. Gaining such knowledge could result in improved care of patients and might avoid the requesting of unnecessary platelet function tests of unproven clinical significance.
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