期刊
LETTERS IN ORGANIC CHEMISTRY
卷 4, 期 1, 页码 68-71出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017807780037531
关键词
ionic liquid; silica sulfuric acid; Biginelli-like; [bmim]Br; catalyst; multi-component reaction
Biginelli-like scaffolds were synthesized in good yields by a three-component condensation reaction of 5,5-dimethyl-1,3-cyclohexanedione, an aldehyde and urea, N-methylurea or thiourea in 1-butyl-3-methylimidazolium bromide ([bmim]Br) as ionic liquid (IL) in the presence of silica sulfuric acid (SSA) as solid acid catalyst at 100 degrees C within less than 2 hours.
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