期刊
AUTOPHAGY
卷 3, 期 1, 页码 35-37出版社
LANDES BIOSCIENCE
DOI: 10.4161/auto.3311
关键词
pexophagy; vacuole; peroxisomes; phosphoinositides; sterol
类别
We recently showed that, in the yeast Pichia, pastoris, an ergosterol glucoside synthesizing enzyme, Atg26, is recruited to the precursor of the pexophagic structure, micropexophogic membrane apparatus (MIPA), under the regulation of phosphatidylinositol 4'-monophosphate (PI4P)-signaling during pexophagy. Atg26 was found to harbor a novel PI4-binding motif, the GRAM domain. Both lipids, PI4P and sterol glucoside, synthesized by PpPik1 and PpAtg26, respectively, were necessary for pexophagy, in the step where the MIPA was formed. In this addendum, we review these findings, and speculate on the mechanistic and physiological implications of the functions of these lipids during the autophagic process.
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