Multicomponent solvent-free cyclocondensation/glycosylation strategy for thiazolo-s-triazine N-nucleosides

A green protocol involving novel three-component one-pot cyclocondensation reactions of 2-amino-4-aryl-thiazoles, aromatic aldehydes and ammonium thiocyanate under solvent-free microwave irradiation (MWI) conditions expeditiously yields thiazolo-s-triazine nucleobases, which afford the corresponding pyrano N-nucleosides on I-2 promoted glycosylation with 1,2,3,4-tetra-O-acetyl-beta-D-ribo/xylopyranose under MWI followed by deacetylation.