期刊
CURRENT OPINION IN PHARMACOLOGY
卷 7, 期 2, 页码 225-232出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2006.09.010
关键词
-
Ryanodine receptors RyRs) function as intracellular Ca2+ release channels on the endoplasmic and sarcoplasmic reticulum membranes. In striated muscles, Ca2+ release through RyRs controls muscle excitation-contraction coupling. RyR channel function is regulated by a cytoplasmic scaffold domain that forms a macromolecular signaling complex including calstabin (formerly known as FK506-binding protein), calmodulin, phosphodiesterase, kinase and phosphatase proteins. An increasing number of genetic and acquired diseases has been associated with intracellular Ca2+ leak. In heart failure, for instance, the RyR complex becomes altered, resulting in chronic channel dysfunction and chronic sarcoplasmic reticulum Ca2+ leak. Recently, the efficacy of novel Ca2+ release channel-stabilizing drugs has been demonstrated in cardiac and skeletal muscle disease models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据