期刊
CANCER LETTERS
卷 345, 期 1, 页码 1-16出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.11.016
关键词
ING1; ING4; Tumor suppressor gene; p53; MicroRNA
类别
资金
- French Ministry of Education and Research
- FRM (Fondation pour la Recherche Medicale) [FDT20130928015]
- INSERM (Institut National de la Sante et de la Recherche Medicale)
- La Ligue Contre le Cancer (Grand Quest)
- Association pour la Recherche sur le Cancer (ARC)
- Rennes Metropole (AIS)
- Actions Incitatives (Universite Rennes 1)
- ANR
- Leucemie Espoir grants
ING genes (ING1-5) were identified has tumor suppressor genes. ING proteins are characterized as Type II TSGs since they are involved in the control of cell proliferation, apoptosis and senescence. They may also function as Type I TSGs since they are also involved in DNA replication and repair. Most studies have reported that they are frequently lost in human tumors and epigenetic mechanisms or misregulation of their transcription may be involved. Recently, studies have described that this loss may be caused by microRNA inhibition. Here, we summarize the current knowledge on ING functions, their involvement in tumor suppression and, in order to give a full assessment of the current knowledge, we review all the studies that have examined ING status in human cancers. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据