期刊
CANCER LETTERS
卷 345, 期 1, 页码 132-139出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.12.006
关键词
Pancreatic ductal adenocarcinoma; Cancer associated fibroblast cells; Tumor microenvironment; Retinoic acid; EMT; Tumor migration
类别
资金
- National Natural Science Foundation, China [81172334]
Retinoic acid (RA) is a small molecular derivative of vitamin A that is stored in quiescent stellate cells in pancreas stroma. Cancer associated fibroblasts (CAFs) are activated fibroblast cells in pancreatic ductal adenocarcinoma tumor microenvironment We treated CAFs with RA and found that these cells became static due to the low expression of oc-SMA, FAP, and IL-6 and decreased production of extracellular matrix (ECM). Furthermore, we verified that the low secretion of IL-6 from CAFs was related to RA-induced inhibition of migration and epithelial-mesenchymal transition (EMT) of tumor cells. However, RA could not inhibit the migration and EMT of tumor cells directly. Therefore, our study showed that one of the therapeutic effects of RA on tumor cells is through its modulation of CAFs in tumor microenvironment The tumor microenvironment plays an important role in promoting tumor migration and might be a promising target of biological treatment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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