期刊
CANCER LETTERS
卷 343, 期 2, 页码 147-155出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.09.039
关键词
Tumour microenvironment; Pancreatic cancer; Stroma; Pancreatic Stellate Cells
类别
资金
- Medical Research Council
- Cancer Research UK
- Cancer Research UK [11563] Funding Source: researchfish
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant stromal response also known as a desmoplastic reaction. Pancreatic Stellate Cells have been identified as playing a key role in pancreatic cancer desmoplasia. There is accumulating evidence that the stroma contributes to tumour progression and to the low therapeutic response of PDAC patients. In this review we described the main actors of the desmoplastic reaction within PDAC and novel therapeutic approaches that are being tested to block the detrimental function of the stroma. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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