期刊
EXPERT REVIEW OF PROTEOMICS
卷 4, 期 2, 页码 149-159出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.4.2.149
关键词
bioinformatics; CID; ECD; ETD; FT-ICR; mass spectrometry; phosphoproteomics; phosphorylation; post-translational modification; proteomics
Protein phosphorylation is a widespread and important post-translational modification. Despite recent advances in phosphoproteomic methods, phosphopeptide identification and site localization remain challenging. Electron capture dissociation has inherent advantages for phosphorylation analysis. The use of electron capture dissociation in this area to date is reviewed and future prospects are outlined.
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