期刊
CANCER LETTERS
卷 353, 期 2, 页码 201-210出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.07.026
关键词
MicroRNA; miR-370; Endoglin; Endometrioid ovarian cancer; Target gene
类别
资金
- Medical Development Fund of Soochow University [EE1234]
- Science and Technology Development Fund of Yancheng City [YK2009089]
MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally inhibit gene expression. In this study, we discovered that microRNA-370 (miR-370) was down-regulated in endometrioid ovarian cancer cells. In IGROV1 and TOV112D endometrioid ovarian cancer cells, miR-370 suppressed cellular viability and colony formation. miR-370 also enhanced endometrioid ovarian cancer cell chemosensitivity to cDDP. Endoglin (ENG) was directly and negatively regulated by miR-370. In addition, hypermethylation was a potential mechanism of miR-370 epigenetic silencing. We conclude that miR-370 acts as a tumor suppressor in endometrioid ovarian cancer via ENG regulation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据