期刊
OBESITY REVIEWS
卷 8, 期 2, 页码 169-181出版社
WILEY
DOI: 10.1111/j.1467-789X.2006.00277.x
关键词
circadian; clock; obesity; sleep
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL074259] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL074259] Funding Source: Medline
Obesity is one of the most profound public health problems today, and simplistic explanations based on excessive nutritional consumption or lack of physical activity are inadequate to account for this dramatic and literal growth in our world population. Recent reports have suggested that disruptions in sleep patterns, often linked to our '24-h' lifestyle, are associated with increased body fat and altered metabolism, although the cause-effect relationship for these associations has yet to be elucidated. Abnormal sleep/wake patterns likely alter intracellular circadian clocks, which are molecular mechanisms that enable the cell/tissue/organism to anticipate diurnal variations in its environment. The environment may include circulating levels of nutrients (e.g. glucose, fatty acids and triglycerides) and various hormones (e.g. insulin, glucocorticoids). As such, alterations in this molecular mechanism, in particular within the adipocyte, likely induce metabolic changes that may potentiate disrupted metabolism, adipose accumulation and/or obesity. Although diurnal variations in adipokines and adipose tissue metabolism have been observed, little is known regarding the molecular mechanisms that influence these events.
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