Humanized NOD-SCID IL2rg-/- mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg(-/-) mice are more permissive for human cells and tissue engraftment In this review, we discuss the use of NOD-SCID-IL2re(-/-) mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies. (C) 2013 Elsevier Ireland Ltd. All rights reserved.