期刊
CELL RESEARCH
卷 17, 期 3, 页码 195-211出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cr.7310149
关键词
histone deacetylase; histone; post-translational modification; transcription; historic deacetylase inhibitors; protein acetylation
类别
Histone deacetylases (HDACs) and historic acetyl transferases (HATs) are two counteracting enzyme families whose enzymatic activity controls the acetylation state of protein lysine residues, notably those contained in the N-terminal extensions of the core histories. Acetylation of histories affects gene expression through its influence on chromatin conformation. In addition, several non-histone proteins are regulated in their stability or biological function by the acetylation state of specific lysine residues. HDACs intervene in a multitude of biological processes and are part of a multiprotein family in which each member has its specialized functions. In addition, HDAC activity is tightly controlled through targeted recruitment, protein-protein interactions and post-translational modifications. Control of cell cycle progression, cell survival and differentiation are among the most important roles of these enzymes. Since these processes are affected by malignant transformation, HDAC inhibitors were developed as antineoplastic drugs and are showing encouraging efficacy in cancer patients.
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