期刊
CANCER LETTERS
卷 347, 期 1, 页码 46-53出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.02.006
关键词
Gold nanoparticle; Breast neoplasms; Theranostics; Nanotechnology
类别
资金
- SoonChunHyang University Research Fund
- National Institutes of Health [1R01CA132032, 1R01CA155446, U01CA151886]
- Department of Defense [PC111832]
- MD Anderson Institutional Research Grant
Despite remarkable achievements in the treatment of breast cancer, some obstacles still remain. Gold nanoparticles may prove valuable in addressing these problems owing to their unique characteristics, including their enhanced permeability and retention in tumor tissue, their light absorbance and surface plasmon resonance in near-infrared light, their interaction with radiation to generate secondary electrons, and their ability to be conjugated with drugs or other agents. Herein, we discuss some basic concepts of gold nanoparticles, and early results from studies regarding their use in breast cancer, including toxicity and side effects. We also discuss these particles' potential clinical applications. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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