期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 11, 期 3, 页码 279-290出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.11.3.279
关键词
malaria; Plasmodium; protein kinase; selectivity; structure-based design; transmission-blocking
Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cancer and neurodegenerative pathologies. The characterisation of the kinome of the human malaria parasite Plasmodium falciparum has revealed profound divergences, at several levels, between PKs of the parasite and those of its host. Here, the authors review the major issues and recent advances regarding the development of Plasmodium-selective PK inhibitors, with emphasis on target identification and validation, and on structure-based design. The authors also discuss the possibility of interfering with: i) Plasmodium PKs regulating transmission to the mosquito vector; and ii) host PKs that may be required for parasite survival.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据