期刊
CANCER LETTERS
卷 344, 期 2, 页码 166-173出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.11.004
关键词
MicroRNA; MiR-200; EMT; Stem cells; ZEB; Cell cycle
类别
资金
- American Cancer Society Research Scholar Grant [RSG-13-265-01-RMC]
- NIH/NCI R21 Grant [5R21CA160280]
MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene expression at posttranscriptional/translational level. They not only play crucial roles in normal developmental progress, but also are commonly dysregulated in human diseases, including cancer. MiR-200 is a family of tumor suppressor miRNAs consisting of five members, which are significantly involved in inhibition of epithelial-to-mesenchymal transition (EMT), repression of cancer stem cells (CSCs) self-renewal and differentiation, modulation of cell division and apoptosis, and reversal of chemoresistance. In this article, we summarize the latest findings with regard to the tumor suppressor signatures of miR-200 and the regulatory mechanisms of miR-200 expression. The collected evidence supports that miR-200 is becoming a new star miRNA in study of human cancer. Published by Elsevier Ireland Ltd.
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