期刊
CANCER LETTERS
卷 343, 期 1, 页码 51-61出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.09.014
关键词
GLI1; Hedgehog pathway; Transcriptional regulation; Angiogenesis; Cancer
类别
资金
- NIH from the U.S. Department of Defense [K01-CA118423, W81XWH-11-1-0600]
- Pediatric Brain Tumor Foundation
- Beez Foundation
- Intramural Division of Surgical Sciences Dani P. Bolognesi, Ph.D. Award and Clarence Gardner, Ph.D. Award
We investigated truncated glioma-associated oncogene homolog 1 (TGLI1) that behaves as gain-of-function GLI1 and promotes tumor cell migration and invasion. Herein, we report that TGLI1 had a higher propensity than Gal to enhance glioblastoma angiogenesis and growth, both in vivo and in vitro. TGLI1 has gained the ability to enhance expression of pro-angiogenic heparanase. In patient glioblastomas, TGLI1 levels are correlated with heparanase expression. Together, we report that TGLI1 is a novel mediator of glioblastoma angiogenesis and that heparanase is a novel transcriptional target of TGLI1, shedding new light on the molecular pathways that support tumor angiogenesis and aggressive growth. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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