期刊
CANCER LETTERS
卷 343, 期 2, 页码 156-160出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.09.038
关键词
Target therapy; Renal cell carcinoma; Metastatic disease; Renal tumor; Adjuvant treatment
类别
资金
- Boston Scientific
Background: Advanced renal cell carcinoma is one of the most treatment-resistant malignancies to conventional cytotoxic chemotherapy. The development of new targeted therapy was result of understanding biological pathways underlying renal cell carcinoma. Our objective is to provide an overview of current therapies in metastatic renal cell carcinoma. Methods: MEDLINE/PUBMED was queried in December 2012 to identify abstracts, original and review articles. The research was conducted using the following words: metastatic renal cell carcinoma and target therapy. Phase II and Phase III clinical trials were included followed FDA approval. Total of 40 studies were eligible for review. Conclusion: The result of this review shows benefit of these target drugs in tumor burden, increase progression-free and overall survival and improvement the quality of life compared with previous toxic immunotherapy, although complete response remains rare. Published by Elsevier Ireland Ltd.
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