期刊
CANCER LETTERS
卷 354, 期 2, 页码 254-262出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.08.023
关键词
Chemoresistance; Ovarian cancer; IGF-1R signaling
类别
资金
- ACTREC-IRG, CSIR [27(232)/10-EMRII]
- DBT [BT/PR4141/Med/30/680/2011]
- CSIR
- UGC
The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of cisplatin paclitaxel and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with cisplatin, paclitaxel or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumors of ovarian cancer patients after three to four cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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