期刊
CANCER LETTERS
卷 348, 期 1-2, 页码 29-37出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.03.003
关键词
Acute myeloid leukemia; Nutraceuticals; Calcium; Calpain; Glucopsychosine
类别
资金
- University of Waterloo
- Canadian Foundation for Innovation and Ontario Research Fund
To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoietic cells. It delayed tumor growth and reduced tumor weights in mouse xenograft models without imparting toxicity. Glucopsychosine increased cytosolic calcium and induced apoptosis through calpain enzymes. Extracellular calcium was functionally important for glucopsychosine-induced AML cell death and surface calcium channel expression is altered in AML cells highlighting a unique mechanism of glucopsychosine's selectivity. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.
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