期刊
CANCER LETTERS
卷 348, 期 1-2, 页码 71-76出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.03.009
关键词
Chronic myelogenous leukemia; Bone marrow stromal cells; Tumour microenvironment; Exosomes; Interleukin 8
类别
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- University of Palermo (International Cooperation)
- MURST
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by the Bcr-Abl oncoprotein with constitutive tyrosine kinase activity. Exosomes are nanovesicles released by cancer cells that are involved in cell-to-cell communication thus potentially affecting cancer progression. It is well known that bone marrow stromal microenvironment contributes to disease progression through the establishment of a bi-directional crosstalk with cancer cells. Our hypothesis is that exosomes could have a functional role in this crosstalk. Interleukin-8 (IL 8) is a proinflammatory chemokine that activates multiple signalling pathways downstream of two receptors (CXCR1 and CXCR2). We demonstrated that exosomes released from CML cells stimulate bone marrow stromal cells to produce IL 8 that, in turn, is able to modulate both in vitro and in vivo the leukemia cell malignant phenotype. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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