期刊
CANCER LETTERS
卷 354, 期 1, 页码 5-11出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.08.003
关键词
Flavonoids; Baicalin; Baicalein; Hematological malignancies; Cancer targets
类别
资金
- Technology Development Foundation of Fuzhou University [2013-XQ-8, 2013-XQ-9]
- National Institutes of Health [P50 CA097007, P30 DA028821, R21 MH093844]
- R. A. Welch Foundation Chemistry and Biology Collaborative Grant from the Gulf Coast Consortia (GCC)
- Institute for Translational Sciences (ITS)
- Center for Addiction Research (CAR) at UTMB
- John Sealy Memorial Endowment Fund
- National and Fujian Provincial Key Clinical Specialty Discipline Construction Program
Despite tremendous advances in the targeted therapy for various types of hematological malignancies with successful improvements in the survival rates, emerging resistance issues are startlingly high and novel therapeutic strategies are urgently needed. In addition, chemoprevention is currently becoming an elusive goal. Plant-derived natural products have garnered considerable attention in recent years due to the potential dual functions as chemotherapeutics and dietary chemoprevention. One of the particularly ubiquitous families is the polyphenolic flavonoids. Among them, baicalin and its aglycone baicalein have been widely investigated in hematological malignaucies because both of them exhibit remarkable pharmacological properties. This review focuses on the recent achievements in drug discovery research associated with baicalin and baicalein for hematological malignancy therapies. The promising anticancer activities of these two flavonoids targeting diverse signaling pathways and their potential biological mechanisms in different types of hematological malignancies, as well as the combination strategy with baicalin or baicalein as chemotherapeutic adjuvants for recent therapies in these intractable diseases are discussed. Meanwhile, the biotransformation of baicalin and baicalein and the relevant approaches to improve their bioavailability are also summarized. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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