期刊
CANCER LETTERS
卷 332, 期 1, 页码 94-101出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.023
关键词
MiR-206; Proliferation; CyclinD2; Gastric cancer
类别
资金
- National Natural Science Foundation of China [81172288, 81000864, 30871143]
In this study, we detected miR-206 expression in gastric cancer (GC) and further investigated its effects on GC cell growth in vitro and in vivo. MiR-206 expression was found to be significantly decreased in 30 GC samples and GC cell lines by Real time-KR. Restoration of miR-206 reduced cell growth and colony forming ability in GC cells with G0/G1 cell cycle arrest. Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the CyclinD2 (CCND2). Therefore, we provided evidence that miR-206 was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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