4.7 Article

MiR-206 inhibits gastric cancer proliferation in part by repressing CyclinD2

期刊

CANCER LETTERS
卷 332, 期 1, 页码 94-101

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.023

关键词

MiR-206; Proliferation; CyclinD2; Gastric cancer

类别

资金

  1. National Natural Science Foundation of China [81172288, 81000864, 30871143]

向作者/读者索取更多资源

In this study, we detected miR-206 expression in gastric cancer (GC) and further investigated its effects on GC cell growth in vitro and in vivo. MiR-206 expression was found to be significantly decreased in 30 GC samples and GC cell lines by Real time-KR. Restoration of miR-206 reduced cell growth and colony forming ability in GC cells with G0/G1 cell cycle arrest. Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the CyclinD2 (CCND2). Therefore, we provided evidence that miR-206 was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据