期刊
CANCER LETTERS
卷 335, 期 2, 页码 404-411出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.02.059
关键词
Dose-dense chemotherapy; Dose-escalation chemotherapy; Multidrug resistance; Migration; Invasion
类别
资金
- NIH [CA92880]
- [NNSF-81071880]
- [NNSF-30973456]
Both dose-dense and dose-escalation chemotherapy are administered in clinic. By approximately imitating the schedules of dose-dense and dose-escalation administration with paclitaxel, two novel multidrug resistant (MDR) cell lines Bads-200 and Bats-72 were successfully developed from drug-sensitive breast cancer cell line BCap37, respectively. Different from Bads-200, Bats-72 exhibited stable MDR and significantly enhanced migratory and invasive properties, indicating that they represented two different MDR phenotypes. Our results showed that distinct phenotypes of MDR could be induced by altered administration strategies with a same drug. Administrating paclitaxel in conventional dose-escalation schedule might induce recrudescent tumor cells with stable MDR and increased metastatic capacity. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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