期刊
CANCER LETTERS
卷 337, 期 1, 页码 41-48出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.05.038
关键词
Occludin; Claudin; Tight junction; Cancer; Metastasis
类别
资金
- National Institutes of Health [CA127547]
The tight junction is a multi-protein complex and is the apical most junctional complex in certain epithelial and endothelial cells. A great deal of attention has been devoted to the understanding of these proteins in contributing to the barrier function - that is, regulating the paracellular flux or permeability between adjacent cells. However, tight junction proteins are now recognized as having functions beyond the barrier. The focus of this review is to discuss the barrier function of the tight junction and to summarize the literature with a focus on the role of tight junction proteins in proliferation, transformation, and metastasis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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