期刊
CANCER LETTERS
卷 340, 期 2, 页码 179-191出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.11.010
关键词
RNA-Seq; Alternative splicing; Cancer; Transcriptomes; Bioinformatics
类别
资金
- National Basic Research Program of China [2012CB316504]
- Hi-tech Research and Development Program of China [2012AA020401]
- NSFC [91010016, 61021063]
The biogenesis, development and metastases of cancer are associated with many variations in the transcriptome. Alternative splicing of genes is a major post-transcriptional regulation mechanism that is involved in many types of cancer. The next-generation sequencing applied on RNAs (RNA-Seq) provides a new technology for studying transcriptomes. It provides an unprecedented opportunity for quantitatively studying alternative splicing in a systematic way. This mini-review summarizes the current RNA-Seq studies on cancer transcriptomes especially studies on cancer-related alternative splicing, and discusses the strategy for quantitative study of alternative splicing in cancers with RNA-Seq, the bioinformatics methods available and existing questions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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