期刊
CANCER LETTERS
卷 339, 期 2, 页码 260-269出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.06.018
关键词
miR-146b-5p; MMP16; Gliomas; Migration; Invasion
类别
资金
- Chinese National Programs for Fundamental Research and Development (973 Program) [2010CB529405]
- National Natural Science Foundation of China [30770827]
- Key Laboratory Project of Tianjin Programs for Science and Technology [10SYSYJC28800]
- Tianjin Municipal Science and Technology Commission [10JCZDJC19400]
- Tianjin Municipal High School Science 82 Technology Foundation Project [2004ZD06, 20060202]
miR-146b-5p is frequently down-regulated in solid tumours, including prostate cancer, pancreatic cancer, and glioblastoma. However, the tumour-suppressive effects of miR-146b-5p in malignant gliomas have not been investigated thoroughly. Here, we found that decreased miR-146b-5p expression was strongly correlated with chromosome 10q loss in gliomas, especially glioblastomas. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. Our results suggest that the restoration of miR-146b-5p expression may be a feasible approach for inhibiting the migration and invasion of malignant gliomas. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据