期刊
CANCER LETTERS
卷 332, 期 1, 页码 102-109出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.022
关键词
Deguelin; Breast cancer; Apoptosis; IGFR signaling; IGFBP-3
类别
资金
- National Institutes of Health [R01 CA100816]
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2012-0005721, 2012-0006019]
- Research Settlement Fund for New Faculty of SNU
- National Research Foundation of Korea [2011-0013927] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling activation, and up-regulation of IGF-binding protein-3 (IGFBP-3) expression may be associated with deguelin-mediated antitumor effects. Our findings suggest a potential therapeutic use for deguelin in patients with triple-negative breast cancer and for those with breast cancers who are sensitive to endocrine- and HER2-targeted therapies. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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