期刊
CANCER LETTERS
卷 334, 期 1, 页码 101-108出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.08.026
关键词
Withaferin A; Breast cancer; Apoptosis; XIAP; Survivin
类别
资金
- USPHS [RO1 CA142604-03]
- National Cancer Institute
The present study provides novel insight into the mechanism of apoptosis induction by withaferin A (WA), which is a bioactive constituent of an Ayurvedic medicine plant (Withania somnifera). Exposure of MDA-MB-231 and MCF-7 human breast cancer cells to WA resulted in suppression of XIAP, cIAP-2, and Survivin protein levels. The WA-induced apoptosis was significantly attenuated by ectopic expression of XIAP, Survivin, and cIAP-2 in both cells. However, the WA-mediated inhibition of MDA-MB-231 xenograft growth in vivo was associated with suppression of Survivin protein level only. These results indicate important contribution of Survivin suppression in WA-induced apoptosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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