期刊
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
卷 60, 期 10, 页码 1313-1320出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/17470210701515785
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In animals, the reappearance of conditioned fear responses after extinction has been primarily investigated using single-cue conditioning paradigms. However, a differential paradigm can overcome several of the disadvantages associated with a single-cue procedure. In the present study, the reinstatement phenomenon was assessed in mice using a differential conditioned suppression paradigm. In a first phase, one conditioned stimulus (CS+) was consistently paired with an unconditioned stimulus (US; footshock) while another CS (CS-)was not, resulting in selective suppression of previously trained instrumental behaviour during the CS+. After the extinction phase, half of the animals (reinstatement group) were presented with unsignalled USs, while the other half were not (control group). A differential return of conditioned responding was observed in the reinstatement group, but not in the control group. The implications of these findings for future conditioning research are discussed.
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