期刊
HIPPOCAMPUS
卷 17, 期 11, 页码 1060-1070出版社
WILEY
DOI: 10.1002/hipo.20338
关键词
functional MRI; memory; entorhinal cortex; perirhinal cortex
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR014075] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K23NS002189] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K23AG022509, R01AG008441] Funding Source: NIH RePORTER
- NCRR NIH HHS [P41 RR014075, P41-RR14075] Funding Source: Medline
- NIA NIH HHS [R01-AG08441, K23-AG22509, K23 AG022509, K23 AG022509-05, R01 AG008441] Funding Source: Medline
- NINDS NIH HHS [K23-NS02189, K23 NS002189] Funding Source: Medline
The ability to spontaneously recall recently learned information is a fundamental mnemonic activity of daily life, but has received little study using functional neuroimaging. We developed a functional MRI (fMRI) paradigm to study regional brain activity during encoding that predicts free recall. In this event-related fMRI study, ten lists of fourteen pictures of common objects were shown to healthy young individuals and regional brain activity during encoding was analyzed based on subsequent free recall performance. Free recall of items was predicted by activity during encoding in hippocampal, fusiform, and inferior prefrontal cortical regions. Within-subject variance in free recall performance for the ten lists was predicted by a linear combination of condition-specific inferior prefrontal, hippocampal, and fusiform activity. Recall performance was better for lists in which prefrontal activity was greater for all items of the list and hippocampal and fusiform activity were greater specifically for items that were recalled from the list. Thus, the activity of medial temporal, fusiform, and prefrontal brain regions during the learning of new information is important for the subsequent free recall of this information. These fronto-temporal brain regions act together as a large-scale memory-related network, the components of which make distinct yet interacting contributions during encoding that predict subsequent successful free recall performance. (C) 2007 Wiley-Liss, Inc.
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