期刊
CANCER LETTERS
卷 333, 期 1, 页码 96-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.01.031
关键词
TRPM7; Breast cancer; Invasion; Src; MAPK
类别
资金
- National Basic Research Program of China [2012CB518200, 2012CB525004]
- National Natural Science Foundation of China [30971193, 81071611]
Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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