期刊
CANCER LETTERS
卷 329, 期 1, 页码 84-90出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.10.019
关键词
Colorectal cancer; MiR-429; Prognosis; Apoptosis; SOX2
类别
资金
- National Natural Science Foundation of China [30672010]
- Shandong Province Natural Science Foundation of China [ZR2010H004, ZR2009CQ038]
- National Key Clinical Medical Specialties Foundation
Emerging evidence has demonstrated that microRNAs (miRNAs) can act as oncogenes or tumor suppressors to participate in cancer development. In this study, we found that miR-429 expression was up-regulated in human colorectal cancer (CRC) tissues, and the high miR-429 expression was significantly associated with tumor size, lymph node metastasis and poor prognosis. Functionally, miR-429 overexpression suppressed cell apoptosis by directly targeting SOX2 in HT-29 cells. Taken together, our data suggest for the first time that miR-429 could play an oncogenic role in the cellular processes of CRC and represent a novel prognostic biomarker for CRC. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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