期刊
CANCER LETTERS
卷 334, 期 1, 页码 34-38出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.07.016
关键词
Tobacco smoke; Biomarkers; Cotinine; NNAL; PheT; NNN
类别
资金
- US National Institutes of Health [CA-129534, CA-144034, CA-92025, CA-81301]
Metabolites of tobacco smoke constituents can be quantified in urine and other body fluids providing a realistic measure of carcinogen and toxicant dose in a smoker. Many previous studies have demonstrated that these metabolites - referred to as biomarkers in this paper - are related to tobacco smoke exposure. The studies reviewed here were designed to answer another question: are these substances also biomarkers of cancer risk? Using a prospective study design comparing biomarker levels in cancer cases and controls, all of whom were smokers, the results demonstrate that several of these biomarkers - total cotinine, total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), r-1-,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetra-hydrophenanthrene (PheT), and total N'-nitrosonornicotine (NNN) - are biomarkers of cancer risk. Therefore, these biomarkers have the potential to become part of a cancer risk prediction algorithm for smokers. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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