期刊
CANCER LETTERS
卷 341, 期 2, 页码 111-126出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.08.006
关键词
Clear cell renal cell carcinoma; Chromosomal aberrations; Large-scale sequencing; Gene expression; miRNA; DNA methylation
类别
资金
- FOCUS program [3/2008]
- Polish Foundation of Science
- scholarship for young post-doc AMU: Unique Graduate = Possibilities [POKL.04.01.01-00-019/10]
- European Union within the European Social Fund
Majority of clear cell renal cell carcinomas (ccRCCs) are diagnosed in the advanced metastatic stage resulting in dramatic decrease of patient survival. Thereby, early detection and monitoring of the disease may improve prognosis and treatment results. Recent technological advances enable the identification of genetic events associated with ccRCC and reveal significant molecular heterogeneity of ccRCC tumors. This review summarizes recent findings in ccRCC genomics and epigenomics derived from chromosomal aberrations, DNA sequencing and methylation, mRNA, miRNA expression profiling experiments. We provide a molecular insight into ccRCC pathology and recapitulate possible clinical applications of genomic alterations as predictive and prognostic biomarkers. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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