期刊
CANCER LETTERS
卷 334, 期 1, 页码 28-33出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.08.027
关键词
Prostate cancer; Estrogens; Androgens; Hormonal carcinogenesis
类别
资金
- NIH [CA159385, CA136027, CA104334, CA75293, CA48084]
Androgens are thought to cause prostate cancer, but the precise mechanisms by which they do so are unclear. Data, mostly from animal studies, suggest that for androgens to cause prostate cancer they must be aromatized to estrogen and act in concert with these estrogen metabolites. Androgen-receptor mediated activity of androgens and estrogen receptor-mediated effects of estrogen metabolites are likely to be necessary, but estrogen genotoxicity appears to be a probable critical factor as well. Only when all these mechanisms are active, may prostate carcinogenesis result. Convincing proof-of-concept studies are needed to definitively test this concept which, if proven, may lead to clinically feasible chemoprevention approaches interfering with these mechanisms. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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