期刊
CANCER LETTERS
卷 337, 期 2, 页码 293-300出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2013.04.003
关键词
Zinc finger protein X-linked (ZFX); ERK-MAPK; Gastric cancer (GC)
类别
资金
- National Basic Research Program of China (973 Program) [2010CB5293]
- National High Technology Research and Development Program of China (863 Program) [2012AA02A504]
- Program for Innovative Research Team of Shanghai Municipal Education Commission
- National Natural Science Foundation of China [91129724]
Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor encoded on the X chromosome. Here, we found that ZFX expression was significantly upregulated in gastric cancer (GC) cell lines and tissues. Knockdown of ZFX induced significant apoptosis and cell cycle arrest in SGC7901 and MGC803 cells. Moreover, we demonstrated for the first time that knockdown of ZFX inhibited gastric cancer cell growth in vitro and in vivo via downregulating the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) pathway. Therefore, ZFX play a prominent role in GC tumorigenicity and may have potential applications in the diagnosis or treatment of GC. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据